In the past couple of years, stem cell technology has made rapid advances allowing us to now isolate and use a patients’ own stem cells to regenerate damaged joints. Stem cells can regenerate all types of tissues, including car- tilage, bone, ligaments and tendons. Regenerative stem cell injections are a fast effective treatment for rebuilding lost cartilage. Stem cell therapy has been labeled the medicine of the future by many doctors and it is an alternative to traditional surgical approaches. Regenerative Orthopedics may generate a better result, with faster healing time and at less risk in many cases.

Stem cells are gently harvested from the patient and then injected in to the damaged joint area. Orthopedic stem cell therapy is done in a single session and involves a minor outpatient surgery using local anesthesia. The patients’ response to the stem cell therapy depends on their bodies healing response and can range from one to six weeks from a single treatment. The stem cells remain alive and will continue to regenerate and rebuild the damaged joint or ligament for up to six months detecting the tissues that are damaged and repairing those tissues selectively.

The regenerated tissue from the stem cell therapy after the joint or connective tissue structure is regenerated pro- duces long-term results that are minimally invasive and safe. Orthopedic stem cell therapy uses stem cells from the patient’s own body, eliminating any risk of tissue rejection. Stem cell therapy has the ability to heal almost any joint in your body, to determine if you would be a good candidate for stem cells call Dr Stolarski today for an evaluation.

PRP vs BMAC

Platelet-Rich Plasma vs Bone Marrow Aspirate Concentrate

HOW THEY COMPARE

What is PRP?

Platelet-Rich Plasma (PRP) is a concentrated form of whole blood. In this procedure the patient’s blood is drawn from a vein and concentrated in a centrifuge to create a concentrate of platelets in plasma. This concentrate contains approximately 5 times the amount of bioactive proteins and growth factors found in unconcentrated whole blood. These bioactive proteins and growth factors are essential in inducing and accelerating tissue healing and regeneration.

The PRP is injected into, on and around damaged tissues. Most of the benefit is seen in the connective tissues, bone and cartilage, as well as in the development of new blood vessels necessary for tissue healing.

What is BMAC?

Bone Marrow Aspirate Concentrate (BMAC) is a concentrated form of bone marrow, which is a more effective type of regenerative medicine than PRP. In this procedure bone marrow is withdrawn from the patient’s hip bone or leg bone and concentrated in a special centrifuge. In addition to the 5-times concentrate of platelets, bioactive proteins and growth factors found in PRP, BMAC also contains a significant amount of Mesenchymal Stem Cells, which are capable of helping to regenerate more types of tissue to a greater degree than PRP. These Mesenchymal Stem Cells also secrete additional bioactive proteins and growth factors that ac- celerate the tissue healing and regeneration process. These secretions have even been shown to further prevent infection, reduce inflammation and reduce pain.

The BMAC is injected into, on and around damaged tissues. Mesenchymal Stem Cells within the BMAC are capable of differenti- ating into connective tissues, bone, muscle, cartilage, tendon and ligament. They also contribute to the development of new blood vessels necessary for tissue healing. Stem Cell Therapy using BMAC is at the forefront of regenerative medicine today.

CONTENTS & BENEFITS

  • CONTENTS OF PRP

    • Platelets
    • Bioactive Proteins
    • Growth Factors
  • BENEFITS OF PRP

    Helps in the healing and regeneration of – Connective Tissue – Bone – Cartilage

    • Helps to reduce pain
    • Helps in the development of new Blood Vessels
  • CONTENTS OF BMAC

    • The same Platelets, Bioactive Proteins and Growth Factors found in PRP, PLUS
    • Mesenchymal Stem Cells (MSC)
    • MSC secretions of additional Bioactive Proteins and Growth Factors that further prevent infection, reduce inflammation and reduce pain
  • BENEFITS OF BMAC

    • ALL THE BENEFITS OF PRP PLUS
    • Mesenchymal stem cells that can differentiate into: – Muscle – Bone – Connective Tissue / Tendon – Ligament – Cartilage
    • MSC secretions that help to further: – Prevent Infection – Reduce Inflammation – Reduce or Eliminate Pain
  • POSSIBLE COST BENEFITS OF BMAC

    • Elimination of Drains
    • Decreased Risk of Infection
    • Decrease in Use of Post-op Narcotics
    • Reduction in Post-op Blood Transfusion
    • Faster Healing = Decreased Hospital Stay

PLATELETS vs MESENCHEMYCAL STEM CELLS

What are Platelets?

  • Platelets are small disc-like, colorless, anuclear cells that play a major role in the coagulation and healing process.
  • Platelets are found in whole blood.
  • Activated platelets will release key bioactive proteins and growth factors involved in healing and tissue regeneration.

What are Mesenchemycal Stem Cells?

  • Mesenchymal stem cells are multi-potent stem cells that can differentiate into various tissue types including muscle, bone, tendon, ligament and cartilage.
  • Mesenchymal stem cells are found in bone marrow.
  • Mesenchymal stem cells will release additional bioactive proteins and growth factors involved in healing and tissue regeneration that are not found in platelets.
  • Placement of BMAC containing platelets and mesenchymal stem cells into a site in need of repair is a more effective method of treatment than the placement of PRP containing just platelets.

Bone Marrow Aspirate Concentrate / BMAC Common Applications

  • Repetitive Motion Injuries
  • Soft Tissue Injuries
  • Muscle Tears
  • Tendonitis
  • Inflamed Nerves
  • Surgical Wounds
  • Plantar fasciitis
  • Chronic tendon disruptions and inflammatory disease
  • Rotator cuff tendon reconstruction
  • Quadriceps tendon reconstruction
  • Infrapatellar tendon reconstruction
  • Patellar tendon bed reconstruction
  • Peroneal tendon repairs – ankle, hand & wrist
  • Adhesion barriers around nerve repairs
  • Adhesion barriers around nerve transpositions, i.e., ulnar nerve transpositions
  • Chronic tendinosis
  • Chronic tendinitis
  • Medial and lateral epicondylitis
  • Jumpers knee (infrapatellar tendinitis)
  • Rotator cuff tendinosis
  • Greater trochanter bursitis/tendinitis
  • Hamstring tendinitis
  • Quadriceps tendinitis
  • Lateral band syndrome
  • Intra-articular injection for chronic inflammatory disease
  • Intra-articular injection for posttraumatic inflammation
  • Intra-articular injection for degenerative joint disease
  • Intra-articular injection for osteoarthritis
  • Intra-articular injection for rheumatoid arthritis
  • Intra-articular injection for augmenting post-operartive healing
  • Ligamentous reconstructions
  • Lateral ankle reconstructions
  • Anterior and posterior cruciate ligament reconstruction
  • Medial and lateral collateral ligament transpositions reconstruction
  • Hernia repairs
  • Mesh reconstructions from all soft tissue deficits

Regenerative Medicine PRP & BMAC

The Science of Regenerative Medicine

The science of regenerative medicine focuses on accelerated healing, regeneration of tissue and quicker restoration of normal function.

Regeneration of damaged tissue can be accomplished by stimulating the body’s own repair mechanisms with natural regenerative substances such as blood platelets and adult mesenchymal stem cells.

  • Platelets can be concentrated in Platelet-Rich Plasma (PRP).
  • Stem cells can be concentrated in Bone Marrow Aspirate Concentrate (BMAC).?
  • Both procedures are minimally invasive
  • No surgery is required; however, both procudures can be used during surgery
  • Both procedures can now be performed in a physician’s office in less than 30 minutes.

PRP = Platelet-Rich Plasma
BMAC = Bone Marrow Aspirate Concentrate

What is PRP?

Platelet-Rich Plasma (PRP) is a concentrated form of whole blood. In this procedure the patient’s blood is drawn from a vein and concentrated in a centrifuge to create a concentrate of platelets in plasma. This concentrate contains approximately 5 times the amount of bioactive proteins and growth factors found in unconcentrated whole blood. These bioactive proteins and growth factors are essential in inducing and accelerating tissue healing and regeneration.
The PRP is injected into, on and around damaged tissues. Most of the benefit is seen in the connective tissues, bone and cartilage, as well as in the development of new blood vessels necessary for tissue healing.

What is BMAC?

Bone Marrow Aspirate Concentrate (BMAC) is a concentrated form of bone marrow, which is a more effective type of regenerative medicine than PRP. In this procedure bone marrow is withdrawn from the patient’s hip bone or leg bone and concentrated in a special centrifuge. In addition to the 5-times concentrate of blood platelets, bioactive proteins and growth factors found in PRP, BMAC also contains a significant amount of mesenchymal stem cells, which are capable of helping to regenerate more types of tissue to a greater degree than PRP.

Mesenchymal stem cells also secrete additional bioactive proteins and growth factors not found in PRP that accelerate the tissue healing and regeneration process even more. These secretions have even been shown to further prevent infection, reduce inflam- mation and reduce pain.

The BMAC is injected into, on and around damaged tissues. Mesenchymal stem cells within the BMAC are capable of differenti- ating into connective tissues, bone, muscle, cartilage, tendon and ligament. They also contribute to the development of new blood vessels necessary for tissue healing.

Stem Cell Therapy using BMAC and is at the forefront of regenerative medicine today.

Contents of PRP & BMAC

  • Blood Platelets
  • Bioactive Proteins
  • Growth Factors
  • The same Platelets, Bioactive Proteins and Growth Factors found in PRP, PLUS
  • Mesenchymal Stem Cells (MSC)
  • MSC secretions of additional Bioactive Proteins and Growth Factors that further prevent infection, reduce inflammation and reduce pain

Benefits of PRP & BMAC

Helps in the healing and regeneration of – Connective Tissue – Bone – Cartilage

  • Helps to reduce pain
  • Helps in the development of new Blood Vessels
  • ALL THE BENEFITS OF PRP PLUS
  • Mesenchymal stem cells that can differentiate into: – Muscle – Bone – Connective Tissue / Tendon – Ligament – Cartilage
  • MSC secretions that help to further: – Prevent Infection – Reduce Inflammation – Reduce or Eliminate Pain

Cost Benefits

Platelet-Rich Plasma (PRP) is a concentrated form of whole blood. In this procedure the patient’s blood is drawn from a vein and concentrated in a centrifuge to create a concentrate of platelets in plasma. This concentrate contains approximately 5 times the amount of bioactive proteins and growth factors found in un-concentrated whole blood. These bioactive proteins and growth fac- tors are essential in inducing and accelerating tissue healing and regeneration.

The PRP is injected into, on and around damaged tissues. Most of the benefit is seen in the connective tissues, bone and cartilage, as well as in the development of new blood vessels necessary for tissue healing.

PRP Benefits & Conditions

POSSIBLE BENEFITS OF PRP

  • Promote healing
  • Promote new tissue growth
  • Promote quicker restoration of function
  • Reduce pain

CONDITIONS THAT MAY BENEFIT FROM PRP

PRP works best for chronic ligament and tendon sprains and strains including:

  • Rotator cuff injuries
  • Shoulder pain and instability
  • Tennis and golfer’s elbow
  • Hamstring and hip sprains
  • Knee sprains and instability
  • Ankle sprains
  • Patello-femoral syndrome
  • Patellar and Achilles tendinosis
  • Plantar fasciitis
  • Other chronic tendon and ligament problems
  • Osteoarthritis in the knee, hip and other joints.

BMAC Benefits & Conditions

POSSIBLE BENEFITS OF BMAC – ALL THE BENEFITS OF PRP PLUS:

  • Antimicrobial agents prevent infection
  • Anti-inflammatory agents reduce swelling
  • Further reduction or elimination of pain

CONDITIONS THAT MAY BENEFIT FROM BMAC – ALL THE CONDITIONS THAT MAY BENEFIT FROM PRP PLUS:

  • Bone fractures and degenerative bone disease
  • Muscle rips and tears
  • Tendon and ligament rips and tears
  • Loss of cartilage
  • Burns
  • Wounds
  • And more – Consult your physician

Frequently Asked Questions

  • ARE PRP & BMAC COvERED BY INSURANCE?

    Check with your individual plan. Most insurance plans, including Medicare, do not cover all costs involved, but may cover some. Please ask your physician for more information on this topic.

  • DO THE TREATMENTS HURT?

    • PRP – The insertion of needles to draw whole blood and inject the concentrated PRP may hurt just a little. The PRP injection area may be tender for a few days.

    • BMAC – The insertion of needles to inject local anesthesia and inject the concentrated BMAC may hurt just a little. After the marrow draw area is numb, a cannula is inserted into bone to draw out marrow. Bones do not have nerves so there is no pain, just what some patients have described as a feeling of pressure. The BMAC injection area may be tender for a few days.

  • ARE THERE ANY RISKS?

    Any time a needle is placed in the body there is a risk of infection, bleeding and nerve damage. However, these occurrences are extremely rare.

  • WHAT IS THE SUCCESS RATE?

    Some studies show a reduction in healing time of almost 50%. Other studies show 100% healing of chronic injuries and complete relief from pain. Individual results may vary.